Duygu Abbasoğlu

PERSONAL INFORMATION
NameABBASOGLU, Duygu
TitlePhD
Study fieldPharmacogenetics, Pharmacoepigenetics, Gene regulations, Science and Society
E-mail[email protected]
NationalityTurkish
Date of birth22.10.1984
WORK EXPERIENCE
Project coordinator / Apr 2021 – Present“Eskisehir School Institutional Capacity Development Project” European Endowment for Democracy, Eskişehir School Solidarity and Research Association, Eskişehir, Turkiye
Workshop Manager / Sep 2021 – Oct 2021“Opportunities Provided, Problems Created by Technology” Civil Rights Defenders, BirAraDa Association, Turkiye
Workshop Manager / 15 February – 22 March 2021“Pandemic in the Technological Age” BirAraDa Association, Friedrich-Ebert-Stiftung, İstanbul, Turkiye
Workshop Manager / 13 October – 01 December 2020“Our Place in the Ecosystem; Evaluating the Covid-19 Pandemic Based on Past Crises” BirAraDa Association, Heinrich Böll Foundation, İstanbul, Turkiye
Workshop Manager / 27 September – 12 December 2019“From Where to Where Do We Evolve?” Kocaeli Academy for Solidarity, Life Science School Project, Kocaeli, Turkiye.
Expert / 30 April 2012- 30 September 2016Faculty of Pharmacy, Pharmaceutic Toxicology Department, Anadolu University, Eskisehir, Turkiye
Expert / February 2011- April 2012Plant, Drug and Scientific Research Centre (BİBAM), Anadolu University, Eskisehir, Turkiye.
Project researcher 01 April 2009-2011“Genetic Nature of Multi Drug Resistance in Salmonella enterica Subspecies enterica Serovar Infantis’”. Project No: 09B4240008, Ankara, Turkiye
Project assistant 01 June 2008-May 2009“The role of stj fimbrial operon in the intestinal persistence of Salmonella Typhimurium in mice”. The Scientific and Technological Research Council of Turkey (TUBITAK) Project No:107T459, Ankara, Turkiye

ACADEMIC ACTIVIES
Projects
December 2014- Project closed Study of genetic polymorphism profile of liver enzyme CYP3A4 and UGT1A1 in cancer patients treated with irinotecan: Approach pharmacogenetics. Researcher – Anadolu University, Project No 1505F510
May 2014- Project closed Pharmacogenetic and Pharmacoepigenetic Factors for Irinotekan Drug Response in Colon Cancer Treatment. Researcher, Anadolu University Thesis Project, Project No: 1406F310
2009-2011 Genetic Nature of Multi Drug Resistance in Salmonella enterica Subspecies enterica Serovar Infantis. Researcher, Ankara University Project No: 09B4240008.
Poster Publications
23 – 26 September 2018 Duygu Abbasoğlu, Hülya Sivas, Candan Hızel “Pharmacoepigenetics: Epigenetic regulation of UDP glucuronosyltransferase 1A1 (UGT1A1) Enzyme via DNA Methylation in Colon Tissue and Blood Samples of Metastatic Colorectal Cancer (mCRC) Patients Treated with Irinotecan” International Congress on Personalized Health Care (ICPHC 2018), Montreal, Canada 12-15 June 2016 Duygu Abbasoğlu, Meral Günaldı, Hülya Sivas, Cengiz Yakıcıer, Candan Hızel “Association Between Irinotecan Toxicity and Genetic polymorphisms of Drug Metabolic Enzymes in Turkish Cancer Patients” International Congress on Personalised Health Care, Abs.142, Montreal, Canada
12-15 June 2016 Candan Hızel, Duygu Abbasoğlu “Merging Pharmacogenomic and Phenomic Data for Patient Drug Metabolism Efficacy by Help Decision Making System” International Congress on Personalised Health Care, Abs.101, Montreal, Canada
19-21 August 2015 Duygu Abbasoğlu, Meral Günaldı, Hülya Sivas, Cengiz Yakıcıer, Candan Hızel “Relevance of UDP-glucuronosyltransferase polymorphisms in Turkish Colon Cancer patients treated with Irinotecan”, 6th Annual IIAPC Conference, 6th Annual IIAPC Conference Program Handbook, p.30, Montreal, Canada.
25-27 September 2014 D.Abbasoglu, M.Gunaldı, H.Sivas, C.Yakicier, C.Hizel. “The factors affecting UGT1A1 enzyme activity of Irinotecan Drug Response in Turkish Population”, 7th Santorini Conference Biologie Prospective Systems Medicine, Personalized Health and Therapy, Posters’ Abstractsbook, Group B: Pharmacogenomics and Cancer, B2, p.48-49, Santorini, Greece.
25-27 September 2014 P.Kısa, A.Öztürk, U.Kır, K.Demirkılınç, M.Erkan, M.Barbaros, M.Akman, D.Abbasoğlu, Z.Yıldız, İ.Avşar, Ş.Aynacıoğlu, C.Hızel. “The Perceptions Of Pharmacists On Pharmacogenetics and Its Application in Turkey, Greece: A Survey Study”, 7th Santorini Conference Biologie Prospective Systems Medicine, Personalized Health and Therapy, Posters’ Abstractsbook, Group B: Pharmacogenomics and Cancer, B24, p.67-68, Santorini, Greece.
21 April – 23 April 2013 “Investigation of Pharmacogenetic Aspects of Therapy with Acetylcholine Esterase İnhibitors Donepezil and Galantamine in Turkish and French Canadian Alzheimer’s Patients: A Comparative Study for Personalized Medicine” in CINP Thematic Meeting on Pharmacogenomics and Personalised Medicine in Psychiatry, Jerusalem, Israel.
5 August- 9 August 2008 BP-491: ‘Microbiological Analysis of Chicken Meat Consumed in Ankara Region’ in XII. International Congress of Bacteriology and Applied Microbiology, Istanbul, Turkiye.
Published Paper
Duygu Abbasoglu, April 2020. Homo Sapiens’ epidemic test. Birikim, vol. 372, https://www.birikimdergisi.com/dergiler/birikim/1/sayi-372-nisan-2020-372/10037/homo-sapiens-in-salgin-sinavi/11724
Duygu Abbasoglu & Mustafa Akcelık, 2011. Phenotypic and genetic characterization of multidrug-resistant Salmonella Infantis strains isolated from broiler chicken meats in Turkey. Biologia, vol.66/3:1, 406-410
Fatma Kaynak Onurdağ, Selda Özgen, Duygu Abbasoğlu, 2010. Microbiological Investigation of Used Cosmetic Samples. Hacettepe University Journal of the Faculty of Pharmacy, volume 30(1); 1-16.
Fatma Kaynak Onurdağ, Selda Özgen, Duygu Abbasoğlu, Selcan Kasaplar, 2006. Microbiological Analysis of Chicken Meat Served for Consumption in Ankara Region. The Journal of Veterinary Medical Microbiology, Volume 6, Number 1-2, page 33-39.
Oral Presentation
13-16 July 2019 “The Science of Genetics: A Deity or A Weapon?”. Kocaeli Academy for Solidarity, III. Dr.Mehmet Fatih Traş Summer School: Nature, People, Technology: Crises and Possibilities, Balıkesir, Türkiye.
09 May 2019 “The Effect of Technology on Living Things”. Kocaeli Academy for Solidarity, Life Science School Project, Wednesday seminars, Kocaeli, Turkiye.
04 July 2017 ““Technology Effect”. Eskişehir School, Solidarity Seminars 26, Eskişehir, Turkiye.
01-04 April 2015 “Pharmacogenetic and Pharmacoepigenetic Factors for Irinotecan Drug Response in Colon Cancer Treatment in Turkish patients”, International Symposium on Advances in Predictive & Personalized Medicine, Acıbadem University, İstanbul, Turkiye. 23 December 2009 “Salmonella enterica Subspecies enterica Serovar Infantis Suşlarında Çoklu İlaç Dirençliliğin Genetik Doğası”, XVI. National Biotechnology Congress, Antalya, Turkiye.
Author
June 2020 As a practice of resistance: Kocaeli Academy for Solidarity, Life Science School Project. Editors: Yücel Demirer, Metin Aksöz. Chapter 2, Section 4: Two Culturel Issues in the Kocaeli Academy for Solidarity, Life Science School Experience, 202-218, Utopya Press
September 2018 Precision Medicine in Cancers and Non-Communicable Diseases: Prediction, Prevention with Personalization. Part 1, Chapter 5, Candan Hızel, Şükrü Tüzmen, Arsalan Amirfallah, Gizem Çalıbaşı Koçal, Duygu Abbasoğlu, Haluk Onat, Yeşim Yıldırım, Yasemin Baskın. Edt: Debmalya Barh, CRC Press, ISBN: 1351650785, 9781351650786
May 2017 Omics Technologies and Bio-Engineering. Chapter 14: Techniques for nucleic acid engineering: the foundation of gene manipulation, Omics Technologies and Bio-engineering: Towards Improving Quality of Life. Şükrü Tüzmen,Yasemin Baskın, Yağmur Esemen, Serpil Eraslan, Ayşe Feyda Nursal, Gizem Çalıbaşı Koçal, Ayşe Banu Demir, Duygu Abbasoğlu, Candan Hızel Editors: Debmalya Barh & Vasco Azevedo. ISBN: 978-0-12-804659-3
October 2014 Omics Approaches in Breast Cancer. Gülay Büyükköroğlu, Duygu Abbasoğlu, Candan Hizel. “Breast Cancer Gene Therapy” Chap 26 D. Barh (eds.), Omics Approaches in Breast Cancer ISBN: 978-81-322-0842-6 (Print) 978-81-322-0843-3,©Springer
May 2011 Farmasötik Mikrobiyoloji, Editors; Ufuk Abbasoglu, Adile Cevikbas. Chapter 5, Section 5; Rekombinant DNA teknolojisi, 432-456, Chapter 5, Section 7; Antibiyotiklere direnç mekanizmaları, 469-478, Efil press
Social Activities
Eskisehir School, Organization Committee – 3-4 May 2019 5th Political Psychology Conference “Charisma and Leader Cult”, Eskişehir, Turkiye.
Eskisehir School, Organization Committee – 10 February 2018 Panel, Thermal Power Plants: Effects on Air, Agriculture and Health, Eskişehir, Turkiye.
Birarada Association, Independent Organization – Committee 2018- A social and educational platform supported by the academicians who are dismissed from their jobs in Turkiye. İstanbul, Turkiye
Eskisehir School, Second Hand Bazaar for Solidarity. 23 September 2017, 23 December 2017, 09 June 2018, Eskişehir, Turkiye.
Eskisehir School, Independent Organization – Committee 2016- A social and educational platform supported by the academicians who are dismissed from their jobs in Eskisehir. Eskisehir, Turkiye
Organization Committee – Committee 04 May 2013 Understanding Evolution Conference, supports by Eskişehir Metropolitan Municipality and University Council Association, Eskisehir, Turkiye
Organization Committee – General Secretariat 13-16 September 2012 1st International Certificate Program on Predictive and Personalized Medicine/Healthcare in Daily Modern Medicine and Pharmacy, Anadolu University, Eskisehir, Turkiye.
Teaching Experience
Pharmaceutic Toxicology Applications, 2014- 2016 Faculty of Pharmacy, Anadolu University, Eskişehir, Turkiye.
EDUCATION AND TRAINING

Participant / 13-14 May 2017Kadir Has University, Life-Long Education Center, Education of EU project preparation and management, TS EN ISO/IEC 17021-1, AB-0103-YS
Traniee / 15 September-05 October 2013Département d’Oncogénétique, Centre Biomédical de Recherche et Valorisation, Centre Jean Perrin, Clermont-Ferrand, France
Participant / 13-16 September 2012P4 Medicine/Healthcare in Daily Modern Medicine and Pharmacy, McGill University and Anadolu University, Eskisehir
Trainee / 15 June-15 July 2012SPSS Programme Course, Anadolu University, Faculty of Education
Participant / 08-09 March 2012TS EN ISO 9001 Quality Management System Internal Audit Training issued by Turkish Standards Institute, Anadolu University
Trainee / 25-26 May 2011Leica Course on Advanced Confocal&EM/CLEM Techniques, BİBAM, Eskisehir, Turkiye.
Trainee / 2009-2011Ankara University, Prokaryotic Genetics Laboratory, Ankara, Turkiye.
Trainee / 9 June-13 June 2008The course of “Using Molecular Methods to Determinate The Antimicrobial Resistance in Bacteria” organizated by Association of Turkish Microbiology -Study Group of Bacteria Genetics and Ege University Faculty of Medicine, İzmir, Turkiye.
Volunteer / 12-31 August 2005Rehabilitation of burned areas organised by UNAREC in Solsona, Barcelona, Spain
Student / July-August 2006EC English Language School, Malta.
Trainee / 23 August -24 September 2004Trainee in the Ankara Criminal Police Laboratory, Ankara, Turkiye.
DEGREES
DatesSeptember 2012- February 2018
Name and type of organisation providing education and trainingDepartment of Molecular Biology, Graduate School of Natural and Applied Sciences, Anadolu University, Eskişehir, Turkiye
Grade point average3.62 / 4.00
Title of qualification awardedDoctor of Philosophy in Biology
Sufficiency examSuccessful, 17 December 2013
Thesis applicationThesis Title: “Pharmacogenetic and Pharmacoepigenetic Factors for Irinotekan Drug Response in Colon Cancer Treatment” The aim of this study is to describe the effectiveness of irinotecan treatment in individualized approach by analysis of pharmacogenetic, pharmacoepigenetic and response to treatment (phenotypic) of colon cancer patients treated by irinotecan in Turkey.
SN-38 is the active metabolite of the pro-drug irinotecan which is metabolized by which is commonly used in the treatment of metastatic colon cancer. Genetic and epigenetic factors that affect enzyme activity put forward the rational use of drugs. In this study, it is aimed to have predictive data about the outcomes of the genetic and epigenetic factors that may affect UGT1A1 expression on irinotecan drug. This study comprises a total of 48 patients treated with irinotecan. Toxic effect, most commonly diarrhea, mucositis and neutropenia were observed in 66,6% of the patients. The distribution of the genotypes was as follows: 72,98% of them wild type UGT1A1 1*/1* and 6,5% of them recessive UGT1A1 28*/28*. Blood samples of 9 patients and 13 colon tissue samples of 8 patients were collected for epigenetics studies. The methylation profiles of 3rd, 4th, 28th, 29th, and 30th CpG dinucleotides located upstream of transcription start site was investigated. The methylation of -4 CpG dinucleotide in promoter region and -28 CpG and -29 CpG dinucleotides in distal enhancer were detected. Blood samples showed high methylation profiles in all regions compared to tissue samples. UGT1A1 genotypes, patient lifestyle, demographic factors, combined drug use and UGT1A1 CpG dinucleotide methylations were examined by multiple or binary logistic regression model. There was no significant relationship between these factors. This is the first study for the methylation pattern for UGT1A1 in blood samples showing epigenetic regulation might be by tissue-specific methylation of UGT1A1. It is also the first study with irinotecan pharmacoepigenetic so far in Turkiye.
Principal subjects/occupational skills coveredpharmacogenetics, pharmacoepigenetics, SNP’s in Human-Drug metabolisms, polymorphisms, cancer genetics, epigenetic factors, Bisulfide sequencing, western blot analysis (iblot, manuel etc), protein isolation from FFPE samples, PCR methods (nested, gradient etc).
Dates2007 – 2009
Name and type of organisation providing education and trainingDepartment of Biology, Graduate School of Natural and Applied Sciences, Ankara University, Ankara, Turkey
Grade point average3.64 / 4.00
Title of qualification awardedMaster of Science in Biology
Thesis Title: ‘Genetic Nature of Multi Drug Resistance in Salmonella enterica Subspecies enterica Serovar Infantis’: Antibiotic resistance characteristics of 18 Salmonella Infantis strains that were identified by Pulse Field Gel Electrophoresis (PFGE) was investigated by using 16 different antibiotics and it was determined that DMC 40 has a different resistance profile than the other strains. All S. Infantis members’ features of multi drug resistance was found to contain 206.5 kb common plasmid. Conjugation assays were pointed out that the 206.5 kb plasmid has conjugally transfer ability and encoded nalidixic acid resistance property in host strains. To determine the molecular mechanism of nalidixic acid resistance in S. Infantis strains, gyrA gene cluster was amplified with specific primers. As a result of sequence analysis of PCR (Polymerase Chain Reaction) products, Ser83→Tyr (TCC→TAC) point mutation was detected. Detecting this point mutation at gyrA gene site of 206.5 kb size conjugative plasmid confirmed that nalidixic acid resistance characteristic was encoded on this plasmid. End of descriptive PCR (Polymerase Chain Reaction) it was detected that 206.5 kb plasmid had different class I integron from recipient strain and this integron had a relation with gyrA gene.
Principal subjects/occupational skills coveredSalmonella Isolation and Characterization, Gel Electrophoresis, Polymerase Chain Reaction, Pulse Field Gel Electrophoresis, Disc Diffusion and Microdilution Methods, Genomic DNA Isolation, Plasmid DNA Isolation, Spectrophotometric DNA Measurements, Conjugation Assays, Curing Plasmid, Electroporation, Primer Design, Size Measurement of DNA products and Proteins, Basic level bioinformatics (FinchTv, ClustalW, Chromas, MEGA etc.), Horizontal Gene Transfers, Antibiotics, Bacteriocins, Plasmid DNA Isolation from Archea, Genomic DNA Isolation from Mold, Biofilm Structure of Salmonella, Nisin Production and Purification from Lactococcus, Isolation of Nisin, Glycine SDS-PAGE, Tricine SDS-PAGE, Ammonium Precipitation.
Dates2002 – 2007
Name and type of organisation providing education and trainingDepartment of Biology, Faculty of Science, Ankara University, Ankara, Turkiye
Grade point average74.25 / 100
Title of qualification awardedBachelor of Science in Biology